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Dermal-epidermal Junction

Dermal-epidermal Junction

2024-12-06

 

【Introduction】
Dermal-epidermal Junction(DEJ)is a type of extracellular matrix that exists in all organs and tissues in the human body and assumes important functions.Located at the interface between the epidermis and the dermis of the skin, it is a wavy reticular structure with a length of about 0.5 μm to 1 μm,which is the interface and transition structure between the two layers. The main components include type IV and VII collagen,laminin,reticulin/nestin,integrins,and others.Through their cross-linking to form a reticular structure,the basement membrane constitutes a rich variety of biological functions, mainly for the epidermal-dermal connections,signaling function and permeability barrier function.

 

【Chemical Properties】
 The main components include type IV and VII collagen, laminin, reticulin/nestin, integrins, and others.

 

【Advantages】
1、Connection and Support:Dermal-epidermal Junction tightly connects the dermal layer to the epidermal layer. A healthy dermal-epidermal junction holds the epidermal layer firmly,so contributed to the firmness and smoothness of young skin is also a manifestation of a healthy basement membrane.
2、Osmosis:Nutrients and cellular products between the epidermal and dermal layers are transported through dermal-epidermal junction.A healthy dermal-epidermal junction allows the skin to absorb nutrients smoothly,so dermal-epidermal junction is also known as the deep moisturizing nutrient channel of the skin.
3、Barrier function:Dermal-epidermal junction serves as a second barrier within the skin,which can prevent external stimuli from entering the deeper layers of the skin, and at the same time, preventing large molecules such as inflammatory cells from entering the epidermal layer, thereby protecting the skin from inflammation.

 

【Grade】

Cosmetic Grade

 

【Packaging and Storage】

-20°C

 

【Application】

Anti-aged, research and development of skincare products, skin health management, and skin barrier repair.

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